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Rotary has raised more than US$2.9 billion for polio eradication through PolioPlus and partner matches.

Save the Children raised over $2 billion worldwide in the latest audited year across its global movement.

LLS fundraising totals sit in the billions; recent annual revenue is about $368 million, and its Light The Night program has topped $1 billion.

Autism Speaks has raised over $1 billion since 2005 when you include cash donations, events, and in-kind contributions reported in audited filings.

St. Baldrick’s has awarded over $368 million in research grants, with $20,018,890 raised in 2025 and $22,166,554 in 2024.

Across major campaigns, breast cancer awareness has raised well over $6 billion, based on documented lifetime totals.

As of November 6, 2025, Games Done Quick has raised about $57.36 million for charity across all marathons.

Penn State THON has raised more than $254 million for pediatric cancer through Four Diamonds.

Best current estimates put global COVID-19 research funding in the tens of billions of dollars since 2020, though totals vary by method.