For metformin extended-release, the typical ceiling is 2,000 mg daily, raised in 500-mg steps with food under clinician guidance.

In milk chocolate, methylxanthines total about 145 mg per 100 g—about 125 mg theobromine and ~20 mg caffeine.

Daily methylprednisolone needs vary by condition: common oral ranges are 4–48 mg, with higher short courses set by a specialist plan.

Most adults need 2.4 mcg/day of vitamin B12; supplements often range 50–1,000 mcg based on diet, labs, and cause—ask your doctor for a plan.

For methylprednisolone, single oral doses are usually 4–32 mg; higher or IV doses (500–1000 mg) are specialist-only.

Most adults use 200–400 mcg of methylfolate per day; those planning pregnancy follow 400 mcg folic acid unless a clinician advises otherwise.

For aquarium treatment, use 2–3 ppm methylene blue in water—about 1 teaspoon of 2.303% solution per 10 gallons (≈38 liters).

For diagnosed methemoglobinemia, clinicians start methylene blue at 1–2 mg/kg IV of a 1% solution with monitoring.

Daily oral methylene blue varies by purpose; common doses run 10–50 mg per dose, set and supervised by a clinician.

For methylene blue, 1 mg/kg IV is standard in hospitals; self-dosing and higher amounts raise risks like hemolysis and serotonin toxicity.