How Much B6 Is In Diclegis? | Dose, Safety And Uses

When a prescription for Diclegis lands in your hand, one of the first questions that comes up is how much vitamin B6 you will actually take with each dose. That makes sense, because vitamin B6 already appears in food, prenatal vitamins, and sometimes extra supplements.

Diclegis is a delayed-release combination of doxylamine succinate and pyridoxine hydrochloride (vitamin B6) used to treat nausea and vomiting in pregnancy that has not improved with diet changes alone. According to the FDA-approved prescribing information, each tablet provides 10 mg of doxylamine and 10 mg of pyridoxine, released gradually over several hours.

Because the usual schedule involves more than one tablet per day, the total vitamin B6 amount from Diclegis can reach 20–40 mg daily depending on how your dose is adjusted. That is still far below the levels linked with vitamin B6 toxicity in adults, yet it is high enough to help calm pregnancy nausea for many people.

What Is Diclegis And How Vitamin B6 Helps Nausea

Diclegis is a delayed-release tablet taken on an empty stomach, typically at bedtime. The combination pairs doxylamine, an antihistamine that causes drowsiness, with pyridoxine, a form of vitamin B6 that has long been used for morning sickness. Large clinical programs and decades of real-world use show that this combination can reduce nausea and vomiting in early pregnancy for many patients.

Vitamin B6 plays a role in many enzyme reactions in the body, including those that influence neurotransmitters linked to nausea. On its own, vitamin B6 at low oral doses is often tried first for pregnancy nausea. The American College of Obstetricians and Gynecologists (ACOG) lists pyridoxine alone, or pyridoxine with doxylamine, as a first-line medication option when diet changes do not give enough relief.

By combining both substances in one delayed-release tablet, Diclegis offers a steady trickle of vitamin B6 and doxylamine through the night and into the next day. That design aims to blunt early-morning nausea, which can be some of the hardest symptoms to live with during early pregnancy.

How Much B6 Is In Diclegis Per Tablet And Per Day?

The core answer sits in the label: each Diclegis tablet contains 10 mg of pyridoxine hydrochloride, which is vitamin B6 in supplement form, plus 10 mg of doxylamine succinate. That figure does not change between tablets; every tablet carries the same dose.

The total vitamin B6 you receive from Diclegis depends on how many tablets you take in a day. The standard step-up schedule in the prescribing information looks like this:

• Day 1: Two tablets at bedtime (20 mg of vitamin B6).
• Day 2: If symptoms continue, one tablet in the morning and two at bedtime (30 mg of vitamin B6).
• Day 3 and beyond: If symptoms still bother you, one tablet in the morning, one in the mid-afternoon, and two at bedtime (40 mg of vitamin B6).

Your prescriber may tailor this pattern depending on how you respond and how sleepy doxylamine makes you. Some people stay at two tablets nightly because that schedule already gives good relief. Others reach the four-tablet schedule for a while and then taper down once symptoms settle.

To give a clear picture, here is how the vitamin B6 content from Diclegis stacks up across common dosing patterns.

Dosing Scenario	Tablets Per Day	Vitamin B6 From Diclegis (mg)
Single tablet trial dose	1	10
Standard bedtime schedule (Day 1)	2	20
Morning + bedtime (Day 2)	3	30
Full labeled schedule (Day 3 and beyond)	4	40
Two tablets nightly long term	2	20
Three tablets on high-symptom days	3	30
Maximum dose plus separate 10 mg B6 supplement	4 + supplement	50

All of these vitamin B6 figures refer only to Diclegis and any extra B6 supplement you might add. They do not include vitamin B6 from food or from a prenatal vitamin, which also contribute to your total daily intake.

How Diclegis B6 Compares With Other Pregnancy Vitamin B6 Doses

Outside of Diclegis, vitamin B6 alone is often taken at doses of 10–25 mg up to three or four times per day for pregnancy-related nausea, under medical guidance. That can add up to 30–100 mg daily from supplements alone, depending on the schedule chosen.

By contrast, even the highest standard Diclegis dose of four tablets per day gives 40 mg of vitamin B6 from the medication. A prenatal vitamin may add another 1–10 mg. Daily food intake usually brings several more milligrams, since vitamin B6 appears in poultry, fish, potatoes, bananas, and fortified grains.

The National Institutes of Health Office of Dietary Supplements lists 1.9 mg as the recommended daily intake of vitamin B6 in pregnancy for general nutrition, with an upper limit of 100 mg per day for adults when diet and supplements are combined. That upper limit aims to prevent nerve problems that can appear with very high long-term vitamin B6 intake.

When you compare those reference numbers with a Diclegis schedule, even four tablets per day leave a wide margin under the 100 mg level, especially if you are not stacking extra high-dose B6 supplements on top. That is one reason this medication has an established record as a first-line option for nausea and vomiting of pregnancy in several practice guidelines.

At the same time, regulators in some regions now set lower supplement limits for vitamin B6, since rare cases of neuropathy have appeared at long-term doses below 100 mg. Because of that, it still makes sense to keep an eye on everything you take that contains vitamin B6, including Diclegis, prenatal vitamins, and any extra B-complex products.

Tracking Your Total Daily Vitamin B6 Intake With Diclegis

The safest way to think about vitamin B6 and Diclegis is to sum up every source you take in a day. That includes:

• Diclegis tablets.
• Your prenatal or multivitamin.
• Any stand-alone vitamin B6 or B-complex supplement.
• Regular food and drinks.

Food usually contributes modest doses compared with supplements. Most of the variability comes from medication and supplement choices. The simple table below shows how different combinations can stack up.

Source Combination	Approximate Vitamin B6 Intake (mg/day)	Notes
Diet alone with no supplements	1.5–3	Typical intake from food in an adult diet
Prenatal vitamin only	5–15	Varies by brand and label
Two Diclegis tablets + prenatal vitamin	25–35	Common early treatment plan
Four Diclegis tablets + prenatal vitamin	45–55	Full schedule during peak symptoms
Four Diclegis tablets + prenatal + 25 mg B6 supplement	70–80	Still under the 100 mg adult upper limit
Four Diclegis tablets + multiple high-dose B6 products	Over 100	May approach levels tied to neuropathy risk over time
Diet + prenatal + low-dose B-complex with 5 mg B6	10–20	Common pattern for people not using Diclegis

These numbers are rough but practical. Labels on your own products will give the exact values. When you add them up, you can bring that list to your obstetric provider so you can review the total together and adjust anything that seems higher than needed.

How To Take Diclegis So The B6 Dose Works For You

Diclegis tablets must be swallowed whole with water. The delayed-release design depends on the coating staying intact; chewing, crushing, or splitting the tablets changes the way both vitamin B6 and doxylamine enter the bloodstream. The label directs patients to take the tablets on an empty stomach, two to three hours before a meal, which fits well with taking the bedtime dose after the last evening snack.

Drowsiness is the main side effect people notice, since doxylamine is an antihistamine commonly used in sleep aids. The bedtime dose helps shift most of that drowsiness into sleeping hours, but some people still feel groggy in the morning. If that happens, your clinician can adjust timing or reduce the morning dose while watching whether nausea control stays acceptable.

Vitamin B6 itself rarely causes side effects at the doses found in Diclegis. Tingling, numbness, or burning sensations in the hands or feet are classic warning signs of vitamin B6 toxicity, but those problems usually appear only with very high doses taken over long periods, often well above 100 mg per day from supplements alone. With Diclegis, nerves still deserve attention, yet routine daily use within labeled limits has not shown a strong link to these problems.

Because Diclegis contains an antihistamine, combining it with other sedating medications can intensify sleepiness. That includes some allergy pills, sleep aids, and certain anti-nausea medications. Your prescriber can help decide which mix of treatments is safest and still brings enough relief to help you eat and drink comfortably.

When To Talk With Your Doctor About B6 And Diclegis

Any new medication plan in pregnancy deserves a clear conversation with your obstetric provider, and Diclegis is no exception. Bring a full list of everything you take, including over-the-counter supplements, herbal products, and fortified drinks that may contain vitamin B6.

Some situations call for a prompt phone call or visit:

• You cannot keep down fluids for more than 24 hours, even while taking Diclegis.
• You lose weight, feel dizzy when standing, or pass very dark urine.
• You notice tingling, numbness, or burning sensations in your feet or hands.
• You feel so sleepy from the medication that driving or daily tasks no longer feel safe.
• You are already on high-dose B-complex or other supplements that include vitamin B6.

In those situations, your clinician may check lab values, adjust your regimen, add intravenous fluids, or recommend another anti-nausea medication. They can also review whether the total dose of vitamin B6 from all sources still lands in a range that feels comfortable based on your health history, diet, and local guidelines.

Main Points About B6 In Diclegis

Each Diclegis tablet carries 10 mg of vitamin B6, and the full labeled schedule of four tablets per day gives 40 mg from the medicine alone. With a prenatal vitamin and ordinary food intake, most patients remain below the 100 mg adult upper limit described by major nutrition bodies for combined daily intake.

The drug’s long history of use in pregnancy, along with large studies reviewed by organizations such as ACOG and MotherToBaby, gives reassuring safety data when the medication is taken as directed. At the same time, new reviews of vitamin B6 supplements remind everyone that more is not always better, especially with long-term, high-dose products.

If you have been wondering, “How Much B6 Is In Diclegis?” the practical answer is that the amount is modest and predictable: 10 mg per tablet. The real art lies in tailoring the total daily dose, along with your overall vitamin B6 intake from other sources, so you get steady relief from nausea while staying well within safety margins.