In the U.S., Nucala injections list at about $3,837 per 100-mg dose before insurance, with monthly cost driven by the prescribed regimen.
Nucala (mepolizumab) is a prescription biologic given as a subcutaneous injection for several eosinophilic conditions. The headline question most people have is cost. List price is public, but the amount a person pays swings with diagnosis, dose, where the medicine is dispensed, and insurance design. This guide lays out the current list prices, typical monthly totals by indication, and the main ways patients lower out-of-pocket bills.
Nucala Injection Price Today: What A Month Costs
GlaxoSmithKline (GSK) posts wholesale acquisition cost (WAC) figures for each presentation. The most common presentation for adults is a 100-mg prefilled syringe or autoinjector given once every 4 weeks for certain uses. Some conditions use three 100-mg injections on the same day each month. Pediatric severe eosinophilic asthma uses a 40-mg prefilled syringe once monthly. The table below brings the numbers together so you can see list price per unit next to typical monthly quantity by condition.
| Presentation | List Price (Per Unit) | Typical Monthly Quantity |
|---|---|---|
| 100-mg Autoinjector | $3,837.48 (WAC) | 1 unit (asthma/CRSwNP/COPD); 3 units (EGPA/HES) |
| 100-mg Prefilled Syringe | $3,837.48 (WAC) | 1 unit (asthma/CRSwNP/COPD); 3 units (EGPA/HES) |
| 40-mg Prefilled Syringe (ages 6–11) | $1,535.01 (WAC) | 1 unit (pediatric severe eosinophilic asthma) |
| 100-mg Vial (clinic reconstitution) | $3,602.82 (WAC) | 1–3 vials, regimen-dependent |
These WAC figures come from GSK’s July 2025 pricing sheet and match the public GSK list price page. Retail cash quotes from pharmacy discount sites may differ slightly, and specialty-pharmacy handling fees can create variation. The WAC is a benchmark and not a guarantee of the amount billed to a patient.
Why Monthly Totals Differ By Diagnosis
Nucala dosing varies by condition. Adults and adolescents with severe eosinophilic asthma, as well as adults with chronic rhinosinusitis with nasal polyps (CRSwNP) or eosinophilic COPD, receive 100 mg once every 4 weeks. Adults with eosinophilic granulomatosis with polyangiitis (EGPA) or hypereosinophilic syndrome (HES) receive 300 mg once every 4 weeks, given as three separate 100-mg injections on the same day. Children 6–11 with severe eosinophilic asthma receive 40 mg once every 4 weeks. These regimens appear in the current FDA label dosing section.
Ballpark Monthly List Totals
Using the WAC per unit, a single 100-mg injection lists near $3,837 before insurance. Conditions that use three 100-mg injections in a month list near $11,512 for the drug portion. Pediatric dosing with a 40-mg syringe lists near $1,535 per month. If a clinic uses reconstituted 100-mg vials, the drug WAC is slightly lower per vial, and facilities may add an administration charge.
Where The Bill Comes From
People see two types of costs: the drug and the administration. When a person self-injects at home with an autoinjector or prefilled syringe, the plan may treat it like a pharmacy benefit claim. When a clinic gives the dose, the plan may treat it like a medical benefit claim that includes the drug and a procedure code for administration. Coinsurance rates differ across those benefits. Prior authorization is common, and plans often want documented eosinophil counts, diagnosis codes, and prior therapy history.
What Insurance Typically Does
Commercial plans usually apply a copay or coinsurance after any deductible. Many enrollees qualify for a manufacturer copay program that helps with the drug share. Medicare coverage depends on the route. If given in a clinic under buy-and-bill, Part B may apply with 20% coinsurance after the annual deductible, often offset by a Medigap policy. If dispensed for home use, some Part D plans cover it, with tier and coinsurance set by the plan. Because designs vary, the best prediction comes from a benefits check through the program GSK offers.
Ways To Lower Out-Of-Pocket Cost
GSK sponsors programs that estimate coverage and help eligible patients reduce cost. The “Gateway to Nucala” pathway provides benefit verification through a specialty pharmacy and can show projected monthly out-of-pocket before the first fill. Many people with commercial insurance qualify for a copay program that offsets eligible costs up to an annual cap. GSK also runs a patient-assistance program for uninsured or Medicare enrollees who meet income criteria. You can start with the official pages for cost and savings and the patient-assistance program.
Tips That Often Help
- Ask your prescriber to submit the benefits check before the first dose so you know the plan’s coinsurance path and specialty-pharmacy routing.
- Confirm whether your plan covers home injection supplies and shipment fees, if any.
- If both clinic and home options are allowed, compare the net copay/coinsurance for each route across a full year.
- If you change plans, repeat the benefits check, since tiers and prior authorization rules can change the bill.
Real-World Price Checks And Why They Vary
Public cash quotes give a sense of the market. GoodRx and Drugs.com list per-unit prices near the WAC, with small swings by pharmacy network. Some sites show coupon prices, but biologics like this usually flow through specialty channels with plan-specific arrangements. The point is not to pick a pharmacy by the lowest public sticker; the bigger savings usually come from insurance coverage plus a copay program that fills the gap. For reference, see the current Drugs.com price guide.
Example Monthly Scenarios
Below are common scenarios that shape what a person pays at the counter or in a clinic. These are examples, not quotes, and actual costs depend on benefits, accumulators, and eligibility for support programs.
| Coverage Situation | Typical Patient Share | Notes |
|---|---|---|
| Commercial Insurance + Copay Card | Often reduced to a low copay | Copay program may cover eligible costs up to an annual cap; GSK cites up to $9,450 per year for some plans. |
| Medicare Part B (clinic-administered) | Coinsurance after deductible | Many enrollees carry Medigap, which may cover the 20% share when billed under Part B. |
| Medicare Part D (home injection) | Plan-tier coinsurance | Amount depends on the plan’s specialty tier rules and any manufacturer help allowed by law. |
| Uninsured With Assistance | Program-determined | GSK Patient Assistance Program may help those who meet eligibility criteria. |
How Dosing Choices Affect Cost
When a condition calls for 300 mg monthly, the drug portion of the bill triples because it involves three 100-mg injections on the same day each month. EGPA and HES follow that plan. Adults with CRSwNP, eosinophilic COPD, or severe eosinophilic asthma use 100 mg monthly in most cases. Children 6–11 with severe eosinophilic asthma use 40 mg monthly. These details appear in the current FDA label, and the healthcare professional pages spell out in-office and at-home options for multi-injection months.
At-Home vs In-Clinic
Self-injection can reduce travel and may shift the claim to the pharmacy benefit. Clinic dosing can simplify coordination for those already seeing a provider monthly and may place the claim under Part B for Medicare. Plans weigh these settings differently, so a side-by-side benefits check often reveals the lower net cost for a given household.
Step-By-Step Plan To Get Your Price
- Confirm the regimen. Ask your prescriber to note indication and monthly dose (100 mg vs 300 mg; pediatric 40 mg).
- Run a benefits check. Your clinic or specialty pharmacy can run this through the GSK pathway to show expected out-of-pocket across the year.
- Apply savings. Enroll in the copay program if you have commercial coverage and meet the criteria; ask about patient-assistance if uninsured or on Medicare and income-eligible.
- Choose the setting. Compare clinic vs home based on your plan’s math and convenience.
- Track accumulators. Watch how deductibles, out-of-pocket maximums, and any accumulator rules affect month-to-month swings.
FAQ-Style Facts People Ask About Cost
Is There A Generic?
No biosimilar to mepolizumab is on the U.S. market as of this writing. That means pricing reflects brand-name supply. Discount cards on retail sites are less relevant than insurance plus manufacturer support for a specialty biologic.
Will The Price Change Soon?
WAC can move during the year. GSK’s pricing sheet dated July 2025 shows the current amounts listed earlier. Public pages from GSK also quote a similar figure for the 100-mg prefilled options. Plan contracts and specialty-pharmacy fees can change midyear, so a fresh benefits check is wise anytime your insurance switches.
Where Can I Verify These Numbers?
The WAC sheet and the public list-price page are the anchors. You can review the GSK WAC chart for per-unit numbers and the GSK list-price page for the consumer-facing quote. For dosing that drives monthly totals, see the FDA label.
Key Takeaways Before You Fill
- The 100-mg autoinjector or prefilled syringe lists near $3,837 per month when the regimen uses a single injection.
- Regimens that call for three 100-mg injections in a month list near $11,512 for the drug portion.
- The 40-mg pediatric syringe lists near $1,535 per month.
- What a person pays depends on insurance design, setting of care, and eligibility for savings programs.
- A benefits check through the manufacturer pathway gives the best advance view of real-world out-of-pocket.
Method Notes
Pricing data in this article uses the current GSK WAC and public list-price sources and aligns dosing with the FDA label and healthcare professional materials. Retail cash ranges and coupon quotes from pharmacy sites can be helpful for a general feel, but specialty billing and plan contracts tend to shape the bill far more than a walk-up price for biologics.